in Misc ELI5: why is dry skin itchy? What specifically causes dry skin to be itchy? |TTI by Ytima February 13, 2018, 3:30 am 5 Comments ELI5: why is dry skin itchy? What specifically causes dry skin to be itchy? Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Click to share on Google+ (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on WhatsApp (Opens in new window)Like this:Like Loading... Related dryELI5itchyskinspecificallyTTI See more Previous article [WP] You’re a prisoner in a special facility for violent criminals. Today the latest prisoner arrived – a little girl. “That’s cruel,” you tell the guard. “I agree,” he says. “Guess no one cares what happens to the rest of you.” |TTI Next article YSK know about www.gethuman.com, a website dedicated to telling on how to get a real person on the phone when calling a company phone number. |TTI 5 Comments Leave a Reply Things science really doesn’t understand at all: – Brains – Sleep – Itches – Yawns Reply I think it’s because when your skin is dry, it’s more thin due to the lack of moisture. This means that your nerve endings under the skin are more exposed than usual thus making your skin more sensitive. Sensitivity and stimulation of the nerve endings leads and itching and the subsquent relief/pleasure from scratching, respectively. Reply Dry skin is damaged skin cells. Damaged skin cells secret substances that initiate immune response. Itching is an immune response. Reply Its an irritant – when your skin is really dry it gets scaly and it dies easier Your body wants to rid this and scratching is the best relief. Reply We don’t know yet. What we do know, is that at least with mouse models, the itch is NOT immunological, but does follow keratinocyte cornification (which, in a way is thickening). Dry skin has damaged lipid barriers, and it appears that the damaged waterproofing subjects keratinocytes to hypotonic stimulation. This causes them to try to repair the damaged barrier by dividing and forming a thicker cornified layer. Something happens during the cornification process and and natural ligands of itch receptors are released. What these ligands are and if they come directly from keratinocytes is still not known. http://www.jneurosci.org/content/33/22/9283 Reply Leave a Reply Cancel reply Your email address will not be published. Required fields are marked *Comment Name * Email * Website Notify me of follow-up comments by email. Notify me of new posts by email.